Skip to main content
. Author manuscript; available in PMC: 2009 Oct 21.
Published in final edited form as: Nat Neurosci. 2008 Jun 15;11(7):752–753. doi: 10.1038/nn.2139

Figure 2.

Figure 2

Ghrelin signaling regulates social isolation after CSDS. (a) Acylated ghrelin was persistently elevated after CSDS in wild-type C57BL6/J mice (significant effect of treatment, *P < 0.02; post hoc analysis showed no significant effect of day in the control mice; n = 5 in the control group and 10 in the CSDS group). (c) Ghsr−/− mice showed increased social avoidance after CSDS (*P < 0.05). (b,d) Although there is no effect on body weight in any group either during or shortly after CSDS (b), increased food intake was induced during the 10 d of CSDS and maintained for at least 3 d following CSDS in wild-type, but not Ghsr−/−, mice (during CSDS (days 1–10), *P < 0.002; after CSDS (days 11–13), *P < 0.002; n = 6 in each control group, 9 in the wild-type defeated group and 10 in the Ghsr−/− defeated group; d). Data are mean ± s.e.m.