Table 1.
Functional classes of clock proteins across phylaa.
| Class | Ascomycota (Neurospora) |
Arthropoda (Drosophila) |
Chordata (Mus, Homo) |
|---|---|---|---|
| WC-1 | CYC | BMAL1 | |
| +TFs | WC-2 | ||
| CLK | CLOCK | ||
| FRQ | |||
| −Fs | PER | PER 1,2,3 | |
| TIM | |||
| CRY | |||
| CK-1a | DBT | CK1δ/ε | |
| CKA | CK2 | CK2 | |
| PKA | PKA | ||
| Kinases | Shaggy | ||
| PRD-4 | Chk2 | ||
| Chk1 | |||
| ATM | |||
| Phosphatases | PP2A | PP2A | PP2A |
| PP1 | PP1 | ||
| HATs, HDACs | CLOCK SIRT1 |
||
| FWD-1 | SLIMB | β-TRCP | |
| F-boxes | JETLAG | ||
| FBXL3 | |||
a
Proteins implicated in the operation or resetting of core circadian oscillators from three prominent model organisms are listed. Proteins in line with one another share both sequence/domain structure and serve orthologous functions.