Figure 5. Rat brain transplants of M031⁺⁷ and M031⁺¹⁹ hNPCs show improved survival, however, do not induce tumorigenesis.

(A–C) Immunohistochemical stain for human nuclear antigen (hNu) of M031^dip hNPCs, transplanted into the striatum of unlesioned rats in one hemisphere along with (B) M031⁺⁷ and (C) U87 glioma cells in the corresponding hemisphere. M031⁺⁷ (and M031⁺¹⁹; not shown here) hNPCs showed no signs of invasiveness as compared to the positive control U87 glioma cells. (D) The relative proportions of surviving hNu positive cells 6-weeks post-transplantation were noted by visual observation and scored. The overall survival of M031⁺⁷ and M031⁺¹⁹ compared to M031^dip control significantly increased. p value is ** = 0.007, * = 0.01.