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The Est1 and Cdc13 association impacts telomerase activation. The influence of purified Est1, Est1–60, Cdc13, or Cdc13–2 proteins (2.5 nM) alone or in the indicated combinations on telomerase DNA extension activity was determined using DNA substrates with either a 7-base (A) or 23-base (B) single-stranded 3′-overhang and telomerase extract prepared from wild-type yeast. The positions of the loading control primer and the + 1 DNA extension product are marked.
