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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: J Med Chem. 2009 Aug 13;52(15):4716–4724. doi: 10.1021/jm900159g

Figure 5.

Figure 5

1 reduced tumor growth in mouse xenograft models. BT474 (A) or MCF7-VEGFR-3 (B) cells were inoculated into mice subcutaneously. Treatment with 60 mg/kg 1 or vehicle (PBS) was started the day after cell inoculation. Mice were sacrificed 21 days later and tumors were measured for size and weight (Supplemental figure S6). BT474 and MCF7-VEGFR-3 1-treated tumor volumes were significantly smaller than vehicle treated tumors after day 14 (* P<0.01).