Concentrations of reactivation drug used in the DE-candidate vs. optimal drug concentration for KSHV reactivation in single drug studies. Dexamethasone, Ionomycin, and TSA are in μM; NaB and Valproate are in mM; TPA is in nM. The concentrations for the drugs were in discrete concentrations of 0, 0.25, 0.5, 0.75, 1 and 2.5 mM/μM/nM. For the DE-candidate, the concentrations for Dexamethasone and Valproate were four concentration levels lower than the concentration needed for each drug to reactivation KSHV in the individual drug study. TPA and TSA were completely removed in the drug mixture. NaB and Ionomycin were one concentration level higher than in the individual study.