Table 3.
In vitro pharmacokinetic evaluation of 9a-9c.
| Compd | HLM (% remaining) | RLM (% remaining) | PPB (h) (% free) | PPB (r) (% free) |
|---|---|---|---|---|
| 9a | 3.0 | 6.3 | 5.1 | 6.5 |
| 9b | 5.3 | 1.8 | 2.2 | 2.4 |
| 9c | 2.4 | 1.4 | 4.0 | 5.8 |
| 9d | 22 | 20 | 0.8 | 1.6 |
| 9e | 26 | 19 | 1.3 | 2.9 |
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