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Rat pharmacokinetic data for Compounds 9b and 9c.
| 9b | 9c | |||
|---|---|---|---|---|
| Parameters | Plasma | Brain | Plasma | Brain |
| Cmax, (ng/ml or g) | 154 | 1584 | 188 | 1679 |
| Tmax, (h) | 0.5 | 0.5 | 0.5 | 0.5 |
| AUC, (ng·h/mL or g)) | 173 | 705 | 99 | 976 |
| T1/2, (h) | 1.9 | 0.15 | 0.26 | 0.39 |
| Clearance/F, (mL/min/kg) | 894 |
1419 |
||
| AUC(0-8h) brain/AUC(0-8h) plasma | 4.1 | 9.9 | ||
