Table 1.
Hemodynamic parameters in young and mature rats at basal conditions (time 0, before hemorrhage) and at the end of the hemorrhage (180 min) and after resuscitation at (240, 300 and 360 min)
| GROUPS | Time (min) |
Treatment | MABP (mmHg) |
HR (beats/min) |
CI (ml/min/100 g) |
TPRI (mmHg/ml/min/100 g) |
SVI (ml/100 g) |
|---|---|---|---|---|---|---|---|
| Young rats | 0 | Vehicle | 126.5±3.8 | 419.4±8.7 | 27.5±3.7 | 5.1±0.6 | 65.5±8.7 |
| 15d-PGJ2 | 132.9±6.0 | 417.8±9.0 | 23.4±3.0 | 6.8±1.1 | 55.6±6.7 | ||
| during hemorrhage | 180 | Vehicle | 50.9±4.0a | 404.6±15.0 | 11.2±1.3a | 5.4±1.0 | 28.3±3.9a |
| 15d-PGJ2 | 54.2±6.0 | 399.7±9.1 | 14.2±2.3 | 4.7±0.8 | 35.9±5.9 | ||
| Young rats | 240 | Vehicle | 90.9±4.5a | 461.9±18.5 | 18.3±2.4a | 7.0±2.1 | 39.9±5.7a |
| 15d-PGJ2 | 103.8±6.0c | 442.2±9.6 | 17.5±2.9 | 7.4±1.2 | 39.7±7.0 | ||
| during resuscitation | 300 | Vehicle | 85.8±4.9a | 422.3±17.4 | 16.5±3.4a | 8.4±2.5 | 39.1±8.0a |
| 15d-PGJ2 | 95.5±6.4c | 443.8±11.3 | 17.0±2.9 | 7.0±1.3 | 38.4±6.6 | ||
| 360 | Vehicle | 78.4±5.5a | 394.3±20.0 | 15.2±2.7a | 5.4±0.7 | 42.0±6.1a | |
| 15d-PGJ2 | 85.8±6.4c | 418.9±13.2 | 14.9±2.2 | 6.5±0.8 | 36.0±5.6 | ||
| Mature rats | 0 | Vehicle | 138.6±3.5b | 360.6±11.4b | 12.6±0.8b | 11.2±0.6b | 35.4±2.4b |
| 15d-PGJ2 | 138.2±12.0 | 385.0±16.6 | 10.6±1.6 | 15.3±4.1 | 28.1±4.7 | ||
| during hemorrhage | 180 | Vehicle | 50.9±3.7a | 380.2±11.4b | 5.6±0.7ab | 11.5±1.5b | 14.8±1.8ab |
| 15d-PGJ2 | 52.9±5.3 | 391.8±20.1 | 5.6±1.4 | 12.6±4.3 | 13.9±3.9 | ||
| Mature rats | 240 | Vehicle | 106.9±5.8ab | 397.0±15.7b | 12.0±1.9b | 11.8±1.4b | 29.7±4.3b |
| 15d-PGJ2 | 116.4±10.3 | 440.6±26.9 | 13.7±3.1 | 11.2±4.0 | 30.1±5.6 | ||
| during resuscitation | 300 | Vehicle | 97.8±4.4ab | 408.4±10.6b | 12.1±1.9 | 10.9±1.6b | 28.8±4.2b |
| 15d-PGJ2 | 83.8±12.0 | 397.8±24.7 | 10.0±1.4 | 10.3±0.7 | 21.9±6.1 | ||
| 360 | Vehicle | 101.4±5.2ab | 405.1±12.9 | 11.8±2.0 | 10.0±1.2b | 29.1±3.9b | |
| 15d-PGJ2 | 99.6±13.6 | 444.0±28.5 | 9.9±1.3 | 10.4±2.1 | 22.2±6.1 | ||
Values are means ± S.E.M. for 5–35 rats per group. MABP, mean arterial blood pressure; HR, heart rate; CI, cardiac index; TPRI, total peripheral resistance index; SVI, stroke volume index. Hemodynamic parameters were recorded before hemorrhage (basal at time 0), at the end of hemorrhage (180 min) and after resuscitation (at 240, 300 and 360 min).
a
p <. 05 versus basal levels (time 0) of same age group rats
b
p <. 05 versus young rats
c
p <. 05 versus vehicle treatment.