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. Author manuscript; available in PMC: 2009 Oct 21.
Published in final edited form as: J Mol Cell Cardiol. 2008 Mar 12;44(5):882–890. doi: 10.1016/j.yjmcc.2008.03.002

Fig. 1.

Fig. 1

Ang II induced Cx43 protein expression through AT1 receptor in VSMCs. (A) Ang II (10−7 mol/L) induced Cx43 protein expression in SV SMCs in a time-dependent manner. (B) Ang II induced Cx43 protein expression of SV SMCs at 1 h in a dose-dependent manner. The relative amount of Cx43 protein expression was measured by Western blot. (C) Ang II receptor antagonists, losartan (10−6 mol/L, AT1 receptor-specific) and PD-123319 (10−6 mol/L, AT2 receptor-specific), were added to the cultured medium for 30 minutes followed by stimulation of the cells with 10−7 mol/L Ang II for an additional 24 hours. The relative amount of Cx43 protein expression was measured by Western blot. Each bar represents the ratio of Cx43/GAPDH (mean ± SE) from three independent experiments. *P<0.05 compared with control group, §P<0.01 compared with control group, #P<0.01 compared with Ang II group.