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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Nat Biotechnol. 2009 May 3;27(5):478–484. doi: 10.1038/nbt.1539

Figure 3. Selectivity is affected by the number of repeats.

Figure 3

All quantitation of western analysis of protein levels in fibroblast cells is derived from at least three independent experiments. Examples of Western gels used for quantitation are shown in Supplementary Fig. 9 online. (a) Separation by SDS-PAGE of wild-type and mutant HTT protein variants in four different patient-derived cell lines. For (b)–(g) effect on HTT protein expression of adding (b) REP19 to GM04869 cells, (c) REP19N to GM04869 cells, (d) REP19 to GM04719 cells, (e) REP19N to GM04719 cells, (f) REP19 to GM04717 cells, and (g) REP19N to GM04717 cells.