Table 2.

Univariate amputation-free survival rates and hazard ratios in the PREVENT 5III derivation set.

	Covariate	Amputation-free survival	HR (95% CI)	p-value
Female	Yes	75.3	1.08 (0.82–1.41)	0.6
	No	76.7	1.0 (ref)
Age ≥ 75 years	Yes	69.7	1.57 (1.20–2.04)	0.0009
	No	79.4	1.0 (ref)
African American	Yes	73.8	1.19 (0.86–1.64)	0.304
	No	76.8	1.0 (ref)
Statin	Yes	77.7	0.86 (0.66–1.21)	0.27
	No	74.9	1.0 (ref)
Beta-blocker	Yes	76.8	0.93 (0.72–1.22)	0.61
	No	75.4	1.0 (ref)
Anti-platelet	Yes	76.5	0.93 (0.68–1.28)	0.66
	No	74.9	1.0 (ref)
CLI criterion	Tissue loss	72.1	2.50 (1.72–3.66)	<0.0001
	Rest pain	87.5	1.0 (ref)
Diabetes	Yes	73.2	1.57 (1.17–3.00)	0.003
	No	81.7	1.0 (ref)
Insulin controlled diabetes	Yes	72	1.11 (0.82–1.51)	0.51
	No	74.6	1.0 (ref)
Hypertension	Yes	76	1.08 (0.77–1.52)	0.21
	No	77.3	1.0 (ref)
Elevated cholesterol	Yes	73.8	0.78 (0.59–1.00)	0.05
	No	78.9	1.0 (ref)
Smoking (ever)	Yes	79.1	0.59 (0.45–0.78)	0.0002
	No	67.8	1.0 (ref)
History of advanced CAD	Yes	71.9	1.42 (1.10–1.84)	0.008
	No	79.2	1.0 (ref)
CKD class	GFR ≥ 60 (ref.)	81.7	1.0 (ref)
	GFR 30–60	77.8	1.29 (0.93–1.78)	0.13
	GFR 15–30	70.5	1.84 (1.03–3.29)	0.04
	GFR < 15	54.7	3.03 (2.19–4.20)	<.0001
Dialysis	Yes	49.3	3.09 (2.27–4.20)	<0.0001
	No	79.5	1.0 (ref)
Proximal anastomosis site	CFA	77.4	1.0 (ref)
	SFA	75.9	1.11 (0.81–1.54)	0.52
	Popliteal	71.9	1.31 (0.92–1.85)	0.13
Distal anastomosis site	Popliteal	80	1.0 (ref)
	Tibeal	74	1.36 (1.00–1.83)	0.05
	Pedal	77.3	1.24 (0.78–1.99)	0.36
Prior ipsilateral bypass	Yes	79.4	0.82 (0.55–1.21)	0.31
	No	75.6	1.0 (ref)
ABI (median)	>4.2	79	1.0 (ref)
	<4.2	74.9	1.22 (0.88–1.69)	0.24
ABI	>0.3	80.1	1.0 (ref)
	<0.3	75.8	1.24 (0.84–1.83)	0.28
SS-GSV	Yes	76	1.0 (ref)
	No	77.1	1.06 (0.75–1.50)	0.74
Hematocrit < 30	Yes	66.4	1.65 (1.18–2.31)	0.004
	No	77.7	1.0 (ref)
Lymphocyte < 1500	Yes	69.6	1.75 (1.31–2.33)	0.0001
	No	81.5	1.0 (ref)
Weight >75 kg	Yes	78.5	0.79 (0.61–1.03)	0.08
	No	73.7	1.0 (ref)