Figure 8.
p38 MAPK activation and increased ROS production in the heart of TG mice fed high fat diet. (A) Protein levels of MAP kinases and their phosphorylation in the hearts of WT and TG fed a HF or LF diet for 20 weeks. Since p-P38 MAPK was nearly undetectable in LF diet group, no quantitative comparisons among the groups were made. (B) Lipid peroxide content and (C) Frozen heart sections stained with green fluorescence dye DCFDA. Scale bar represents 20 μm. Data are expressed as mean ± SEM from 4-5 hearts for each group. *p < 0.05 vs LFWT.