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Cellular NP uptake and IDV release. Fluorescence microscopy imaging of rDHPE-IDV-NP (red) treated BMM (green, CD68+) demonstrating intracellular localization of IDV-NP (A). Ingested NP appears as red fluorescent dots and is located within the cytoplasm of green CD68+ BMM. BMM-released IDV was assayed by RP-HPLC from cell lysates was performed (B). With subsequent media changes (wash, arrowheads) extracellular (media) and intracellular (BMM) IDV levels diminished (C).
