Table 2.
Resting cardiovascular variables and integrated responses to repeated doses of IMD and AM (Experiment 2)
| IMD (1)1 nmol·kg−1 | IMD (2)1 nmol·kg−1 | AM (1)3 nmol·kg−1 | AM(2)3 nmol·kg−1 | |
|---|---|---|---|---|
| Resting cardiovascular variables | ||||
| Heart rate (beats·min−1) | 349 ± 13 | 354 ± 15 | 374 ± 18 | 377 ± 21 |
| Blood pressure (mmHg) | 111 ± 3 | 108 ± 4 | 110 ± 4 | 117 ± 4 |
| Renal VC (units) | 99 ± 9 | 89 ± 8 | 93 ± 7 | 93 ± 7 |
| Mesenteric VC (units) | 61 ± 5 | 64 ± 6 | 71 ± 8 | 65 ± 7 |
| Hindquarters VC (units) | 49 ± 5 | 48 ± 4 | 49 ± 4 | 46 ± 3 |
| Integrated (0–30 min) responses | ||||
| Heart rate (beats) | +1425 ± 284 | +951 ± 252 | +2315 ± 242 | +2368 ± 431 |
| Blood pressure (mmHg min) | −184 ± 52 | −218 ± 58 | −453 ± 92 | −436 ± 82 |
| Renal VC (% min) | +643 ± 73 | +868 ± 130 | +1328 ± 290 | +1257 ± 221 |
| Mesenteric VC (% min) | +854 ± 106 | +854 ± 117 | +1185 ± 240 | +939 ± 175 |
| Hindquarters VC (% min) | +454 ± 123 | +415 ± 92 | +947 ± 164 | +908 ± 191 |
Values are mean ± SEM, n= 8. Units for VC are (kHz·mmHg−1) 103.
AM, adrenomedullin; IMD, intermedin; VC, vascular conductance.