Table 3.
Resting cardiovascular variables prior to administration of IMD or AM in animals pre-treated with saline or AM22–52 (Experiment 3)
|
Saline |
AM22–52 |
Saline |
AM22–52 |
|
|---|---|---|---|---|
| IMD (1 nmol·kg−1) | AM (3 nmol·kg−1) | |||
| Heart rate (beats·min−1) | 347 ± 10 | 338 ± 9 | 382 ± 14 | 391 ± 8 |
| Blood pressure (mmHg) | 113 ± 7 | 114 ± 3 | 111 ± 4 | 107 ± 5 |
| Renal VC (units) | 62 ± 8 | 92 ± 9a | 94 ± 8 | 107 ± 5 |
| Mesenteric VC (units) | 75 ± 11 | 82 ± 9 | 69 ± 11 | 95 ± 14 |
| Hindquarters VC (units) | 43 ± 8 | 36 ± 3 | 47 ± 4 | 46 ± 4 |
Values are mean ± SEM, n= 6–8 per group. Units for VC are (kHz·mmHg−1) 103.
a
P < 0.05 versus corresponding saline group (Mann–Whitney U-test).
AM, adrenomedullin; IMD, intermedin; VC, vascular conductance.