Table 4.
Resting cardiovascular variables prior to administration of IMD or AM in animals pre-treated with co-infusion of AII+AVP or L-NAME (Experiment 4)
|
AII+AVP |
L-NAME |
AII+AVP |
L-NAME |
|
|---|---|---|---|---|
| IMD (1 nmol·kg−1) | AM (3 nmol·kg−1) | |||
| Heart rate (beats·min−1) | 296 ± 12 | 287 ± 9 | 307 ± 13 | 282 ± 9 |
| Blood pressure (mmHg) | 133 ± 5 | 138 ± 6 | 135 ± 5 | 146 ± 8 |
| Renal VC (units) | 57 ± 9 | 57 ± 9 | 56 ± 7 | 53 ± 12 |
| Mesenteric VC (units) | 36 ± 5 | 31 ± 5 | 31 ± 3 | 28 ± 5 |
| Hindquarters VC (units) | 35 ± 5 | 34 ± 2 | 30 ± 3 | 30 ± 2 |
Values are mean ± SEM, n= 9. Units for VC are (kHz·mmHg−1) 103.
AII, angiotensin II; AM, adrenomedullin; IMD, intermedin; VC, vascular conductance.