Table 6.
Resting cardiovascular variables prior to administration of IMD or AM in animals pre-treated with saline or losartan (Experiment 6)
|
Saline |
losartan |
Saline |
losartan |
|
|---|---|---|---|---|
| IMD (1 nmol·kg−1) | AM (3 nmol·kg−1) | |||
| Heart rate (beats·min−1) | 336 ± 9 | 355 ± 7 | 355 ± 13 | 369 ± 17 |
| Blood pressure (mmHg) | 111 ± 2 | 98 ± 4a | 111 ± 2 | 104 ± 4 |
| Renal VC (units) | 90 ± 10 | 105 ± 12 | 93 ± 12 | 81 ± 14 |
| Mesenteric VC (units) | 74 ± 4 | 89 ± 9 | 77 ± 7 | 83 ± 7 |
| Hindquarters VC (units) | 37 ± 4 | 50 ± 5a | 42 ± 5 | 47 ± 5 |
Values are mean ± SEM, n= 9. Units for VC are (kHz·mmHg−1) 103.
a
P < 0.05 versus corresponding saline group (Wilcoxon's test).
AM, adrenomedullin; IMD, intermedin; VC, vascular conductance.