Figure 2.

Blood pharmacokinetics of radiolabelled panitumumab. Mice (n= 5) bearing s.c. A431 xenografts as well as mice without tumours were given i.v. injections of ¹¹¹In-CHX-A″-panitumumab (∼7.5 µCi) via the tail vein. Blood samples (10 µL) were collected over a 1 week period as described in Methods. The average %ID·mL⁻¹ (percentage of injected dose per millilitre) with the standard deviations is plotted. Panel A presents the first 20 h while Panel B presents the complete study period of 168 h.