Table 2.
Grades of disease on the 12th day after sodium laurate injection
|
Grade of disease |
Significance | |||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | ||
| Normal | 8 | 0 | 0 | 0 | 0 | |
| Sham operated | 8 | 0 | 0 | 0 | 0 | |
| TAO model | 2 | 0 | 0 | 4 | 2 | ** |
| Ucn | 1 | 1 | 0 | 3 | 3 | ** |
| Ucn + NBI-27914 | 5 | 0 | 0 | 2 | 1 | † |
| Ucn + antisauvagine-30 | 2 | 0 | 2 | 1 | 3 | ** |
| Ucn + astressin | 5 | 1 | 1 | 1 | 0 | †# |
On the 12th day after sodium laurate injection, rats from each group were graded according to the gross appearance of the affected paw (see Methods). Kruskal–Wallis H test was carried out to compare the disease condition among groups.
**
P < 0.01, versus sham operated group;
#
P < 0.05, versus TAO model group;
†
P < 0.05, versus Ucn group.
TAO, thromboangiitis obliterans; TAO model, single injection of sodium laurate only; Ucn, TAO model + daily urocortin for 12 days; Ucn + NBI 27914 or + antisauvagine-3 or + astressin, Ucn + daily injections of each antagonist for 12 days.