Table 3A.
Effects of urocortin and CRF1/2 receptor antagonists on rat blood cell counts
| Blood platelet count (108 mL−1) | Red blood cell count (109 mL−1) | Haemoglobin (g·L−1) | Leucocyte count (106 mL−1) | Neutrophil (106 mL−1) | |
|---|---|---|---|---|---|
| Normal | 7.12 ± 0.31 | 6.51 ± 0.31 | 131.25 ± 6.17 | 4.93 ± 0.21 | 1.08 ± 0.20 |
| Sham operated | 7.35 ± 0.51 | 6.21 ± 0.49 | 128.22 ± 4.73 | 5.01 ± 0.40 | 1.16 ± 0.11 |
| TAO model | 9.30 ± 0.49* | 6.11 ± 0.63 | 129.98 ± 7.44 | 5.11 ± 0.61 | 1.19 ± 0.28 |
| Ucn | 11.71 ± 0.72*# | 6.23 ± 0.14 | 130.05 ± 5.10 | 5.08 ± 0.58 | 1.09 ± 0.09 |
| Ucn + NBI-27914 | 7.87 ± 0.62#† | 6.83 ± 0.72 | 135.12 ± 9.39 | 4.95 ± 0.13 | 1.13 ± 0.19 |
| Ucn + antisauvagine-30 | 11.07 ± 0.82 | 6.61 ± 0.42 | 132.26 ± 8.17 | 5.00 ± 0.46 | 1.14 ± 0.24 |
| Ucn + astressin | 7.61 ± 0.71#† | 6.47 ± 0.55 | 128.78 ± 6.85 | 4.97 ± 0.71 | 1.15 ± 0.17 |
Values are presented as means ± SEM (n= 8).
*
P < 0.05, versus sham operated group;
#
P < 0.05, versus model group;
†
P < 0.05, versus urocortin group.
CRF1/2, corticotrophin-releasing factor type 1 and 2 receptors; TAO, thromboangiitis obliterans; TAO model, single injection of sodium laurate only; Ucn, TAO model + daily urocortin for 12 days; Ucn + NBI 27914 or + antisauvagine-3 or + astressin, Ucn + daily injections of each antagonist for 12 days.