Table 3C.
Effects of urocortin and CRF1/2 receptor antagonists on rat blood rheology
| Erythrocyte sedimentation rate (mm·h−1) | Haematocrit (%) |
Blood viscosity |
Plasma viscosity (mPa s) | ||
|---|---|---|---|---|---|
| 200 S−1(mPa s) | 5 S−1 (mPa s) | ||||
| Normal | 1.08 ± 0.23 | 40.88 ± 1.34 | 5.68 ± 0.03 | 11.34 ± 1.39 | 1.39 ± 0.03 |
| Sham operated | 1.15 ± 0.09 | 40.03 ± 0.31 | 5.77 ± 0.28 | 12.01 ± 2.80 | 1.34 ± 0.05 |
| TAO model | 1.11 ± 0.05 | 39.60 ± 0.18 | 5.81 ± 0.41 | 11.73 ± 0.47 | 1.36 ± 0.02 |
| Ucn | 1.09 ± 0.17 | 39.21 ± 0.99 | 5.69 ± 0.18 | 11.58 ± 1.19 | 1.39 ± 0.04 |
| Ucn + NBI-27914 | 1.13 ± 0.20 | 39.67 ± 2.12 | 5.71 ± 0.33 | 11.21 ± 1.30 | 1.34 ± 0.04 |
| Ucn + antisauvagine-30 | 1.16 ± 0.09 | 40.30 ± 2.08 | 5.61 ± 0.01 | 11.94 ± 1.71 | 1.31 ± 0.01 |
| Ucn + astressin | 1.01 ± 0.17 | 39.63 ± 1.62 | 5.73 ± 0.17 | 11.84 ± 1.55 | 1.33 ± 0.02 |
CRF1/2, corticotrophin-releasing factor type 1 and 2 receptors; TAO, thromboangiitis obliterans; TAO model, single injection of sodium laurate only; Ucn, TAO model + daily urocortin for 12 days; Ucn + NBI 27914 or + antisauvagine-3 or + astressin, Ucn + daily injections of each antagonist for 12 days Values are presented as means ± SEM (n= 8).