Table 1.
Participant characteristics, WMH volumes, and comparison by age group
| Characteristic | Age |
p | ||
|---|---|---|---|---|
| All ages (n = 253) | ≥ 60 (n = 121) | < 60 (n = 132) | ||
| Age (years) | 57.8 ± 18.6 | 74.2 ± 8.5 | 42.7 ± 10.9 | <0.001 |
| Education (years) | 13.4 ± 3.4 | 13.2 ± 3.6 | 13.6 ± 3.2 | 0.372 |
| Sex (men) | 123 (48.6) | 62 (51.2) | 61 (46.2) | 0.424 |
| Race (Caucasian) | 181 (71.5) | 92 (76.0) | 89 (67.4) | 0.285 |
| Hypertension | 86 (34.0) | 58 (47.9) | 28 (21.2) | <0.001 |
| Diabetes mellitus | 31 (12.3) | 21 (17.4) | 10 (7.6) | 0.018 |
| Smokers | 61 (24.1) | 22 (18.2) | 39 (29.5) | 0.038 |
| History alcohol abuse/dep.b | 21 (8.3) | 8 (6.6) | 13 (9.8) | 0.323 |
| Body mass index | 27.8 ± 5.5 | 26.6 ± 4.9 | 28.9 ± 5.8 | 0.001 |
| Total WMH (cm3)a | 2.03 ± 5.06 | 3.85 ± 6.85 | 0.36 ± 0.63 | <0.001 |
| Periventricular WMH (cm3)a | 1.53 ± 4.07 | 2.92 ± 5.56 | 0.26 ± 0.40 | <0.001 |
| Subcortical WMH (cm3)a | 0.50 ± 1.37 | 0.93 ± 1.86 | 0.10 ± 0.35 | <0.001 |
Notes: Values are mean ± SD or n (%).
aWMH volumes used in the statistical analyses were adjusted to reflect WMH as a percentage of total brain volume.
bHistory of alcohol abuse or dependence.