Table 3.

Linear associations between WMH and cognitive factor scores in models including age, education, sex, and race

	All ages						Age ≥60
	Total WMH		PV WMH		SC WMH		Total WMH		PV WMH		SC WMH
	R2Δ	R2	R2Δ	R2	R2Δ	R2	R2Δ	R2	R2Δ	R2	R2Δ	R2
Working memory	0.024*	0.346	0.018*	0.341	0.028*	0.351	0.047*	0.374	0.036*	0.363	0.057*	0.384
Processing speed	0.015*	0.574	0.017*	0.577	0.003	0.563	0.019*	0.538	0.021*	0.539	0.007	0.526
Fluency	0.028*	0.356	0.027*	0.356	0.016*	0.345	0.038*	0.417	0.034*	0.413	0.028*	0.407
Crystallized intelligence	0.001	0.589	0.002	0.590	0.000	0.589	0.002	0.579	0.002	0.580	0.000	0.578
Fluid intelligence	0.011*	0.543	0.016*	0.548	0.000	0.532	0.013	0.464	0.020*	0.471	0.000	0.451
Verbal memory	0.012*	0.309	0.012*	0.309	0.006	0.303	0.021	0.230	0.021	0.230	0.010	0.219
Visual memory	0.009*	0.528	0.009*	0.528	0.006	0.525	0.015	0.408	0.014	0.406	0.011	0.403
Executive functioning	0.002	0.262	0.001	0.261	0.004	0.264	0.003	0.420	0.001	0.418	0.008	0.425

Notes: All multiple R² values significant at p < 0.0001.

*p < .05.