Skip to main content
. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: J Hepatol. 2009 May 3;51(1):139–148. doi: 10.1016/j.jhep.2009.03.024

Figure 8. Phagocytosis of AB by HSC induces different survival pathways.

Figure 8

Engulfment of AB induces a JAK1/STAT3 mediated survival pathway leading to an upregulation of Mcl-1. Phagocytosis also induces Akt phosphorylation via the PI3K, and this contributes to NF-κB activation. As a result, the A1 anti apoptotic protein is upregulated in phagocytosing HSC, in a PI3K-dependent manner.

HHS Vulnerability Disclosure