Table 1.

Mean percent blood glucose reduction in normal rats (N = 6)

Time (h)	Gliclazide	Efavirenz	Efavirenz + Gliclazide (Single dose treatment)	Efavirenz + Gliclazide (Multiple dose treatment)
1	31.46 ± 1.39	-06.66 ± 2.95	24.40 ± 1.20***	26.57 ± 1.09*
2	41.64 ± 0.80	-04.44 ± 1.44	33.77 ± 0.87**	36.26 ± 1.53*
3	28.21 ± 0.95	-02.94 ± 0.96	21.19 ± 1.15***	22.26 ± 0.99**
4	24.21 ± 1.13	-00.06 ± 1.80	16.16 ± 0.79***	18.68 ± 0.96***
6	31.47 ± 1.46	02.14 ± 1.49	23.34 ± 1.09***	28.71 ± 1.85
8	38.70 ± 1.43	04.29 ± 1.09	28.36 ± 1.70***	31.21 ± 2.03**
10	26.08 ± 1.02	06.86 ± 1.78	19.00 ± 1.44***	20.45 ± 1.11**
12	12.27 ± 1.55	06.13 ± 1.59	08.27 ± 0.64	08.98 ± 1.02

***Significant at P < 0.001 compared to gliclazide control

**Significant at P < 0.01 compared to gliclazide control

*Significant at P < 0.05 compared to gliclazide control