Figure 1.
Absence of a correlation between radiation sensitivity and heat sensitivity. Panel A shows a cross-correlation of radiation sensitivity, expressed as the dose of X-ray required to kill 90% of the cells, with heat sensitivity, expressed as the equivalent time of heating at 44°C required to kill 90% of the cells, in 30 different mouse cell lines derived from the literature. Panel B shows the comparison of heat sensitivity between various radiosensitive mutants (deficient in either non-homologous end-joining or in homologous recombination) and their isogenic repair proficient counterparts. The average sensitivity of the groups (indicated by the single points with error bars) is not different, nor is there a trend for increase or decrease in heat sensitivity in matched panels (indicated by the lines).