Table 1. Genotype and allele frequencies of interleukin-1β (-511) and interleukin-1β (+3953).
| Genotype |
NTG (%) n= 231 |
Control (%) n=245 |
χ2 |
p-value |
| IL-1β (-511) |
||||
| Genotype |
||||
| C/C |
70 (30.3%) |
61 (24.9%) |
||
| C/T |
108 (46.8%) |
125 (51.0%) |
1.77 |
0.4 |
| T/T |
53 (22.9%) |
59 (24.1%) |
||
| Allele |
||||
| C |
248 (53.7%) |
247 (50.4%) |
1.02 |
0.3 |
| T |
214 (46.3%) |
243 (49.6%) |
||
| IL-1β (+3953) |
||||
| Genotype |
||||
| C/C |
214 (93.8%) |
226 (92.2%) |
||
| C/T |
16 ( 6.9%) |
18 ( 7.3%) |
0.03 |
0.98 |
| T/T |
1 ( 0.4%) |
1 ( 0.4%) |
||
| Allele |
||||
| C |
444 (96.1%) |
470 (95.9%) |
0.02 |
0.88 |
| T | 18 ( 3.9%) | 20 ( 4.1%) |
There was no statistically significant difference in genotype frequency (GF) or allele frequency (AF) distribution of the two polymorphisms between NTG and control subjects. The breakdown was as follows: For IL-1β -511, the AF was p=0.3 and the GF was p=0.4; for IL-1? +3953, the AF was p=0.88 and the GF was p=0.98.