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. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: J Med Chem. 2009 Mar 12;52(5):1471–1476. doi: 10.1021/jm801549b

Table 1.

Binding and Antimicrobial Properties

Compound MIC (µg/mL) Association Constants
S. aureusa E. faecalisb 2c (×105 M−1) 3d (×102 M−1)
1 1.25e 2000e 2.0f 1.8f
5 0.625e 640e 1.7f 1.2f
6 40 800 0.3 2.1
7 20 320 0.9 2.0
8 40 800 2.6 0.8
9 20 320 0.3 2.1
10 31 640 2.0 4.6
11 10 320 1.1 3.5
12 >10 640 0.8 0.8
13 10 320 0.3 1.9
14 10 >400 1.1 1.5
15 1.25 170 1.7 1.5
a

Vancomycin-sensitive (strain ATCC 25923).

b

Vancomycin-resistant (VanA, strain BM4166).

c

N,N′-Ac2-l-Lys-d-Ala-d-Ala.

d

N,N′-Ac2-l-Lys-d-Ala-d-Lac.

e

Taken from ref 18b.

f

Taken from ref 4.