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. Author manuscript; available in PMC: 2010 Apr 22.
Published in final edited form as: J Am Chem Soc. 2009 Apr 22;131(15):5424–5431. doi: 10.1021/ja808704m

Figure 4.

Figure 4

The fragment condensation strategy for the synthesis of EPO(78-113) glycopeptide.a

aThe protected glycans are shown in star shape. Tmb is an abbreviation for 4,5,6-trimethoxy-2-methylthiobenzyl. The dipeptides used in SPPS are underlined. The protected amino acid residues are shown in italic. Reagents and conditions: (a) HATU, DIEA, DMSO, 29%; (b) TCEP•HCl, HOOBt, DIEA, DMSO, 33%; (c) AgCl, HOOBt, DIEA, DMSO, 30%.