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. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: J Med Chem. 2009 Mar 12;52(5):1310–1316. doi: 10.1021/jm801397w

Scheme 2. Synthesis of Fmoc-Lys(MPEG4)-OHa.

Scheme 2

a Key: (a)NaH 0 °C, 1 h; Ethyl bromoacetate, 50 °C, 16 h; (b) 1M LiOH/CH3OH 6h, 59% (from two steps); (c) Perfluorophenol, DCC, overnight; (d) Fmoc-L-lysine, DIPEA, 0 °C, 60% (from two steps).