Skip to main content
. Author manuscript; available in PMC: 2010 Mar 12.
Published in final edited form as: J Med Chem. 2009 Mar 12;52(5):1329–1344. doi: 10.1021/jm801374t

Scheme 7.

Scheme 7

Synthesis of compound 46.a

aReagents and conditions: (a) Dess-Martin periodinane, NaHCO3, CH2Cl2, 0°C, 3 h; (b) triethyl phosphonoacetate, LiCl, DBU, CH3CN, rt, 3 h; (c) Pd/C, H2 (g), rt, 4 h; (d) i) DIBAL-H, CH2Cl2, −78°C, 1 h; ii) 1M HCl (aq); (e) 23, NaBH3CN, AcOH, DMF, 0°C to rt, 4 h.