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. Author manuscript; available in PMC: 2010 Apr 22.

Published in final edited form as: J Am Chem Soc. 2009 Apr 22;131(15):5564–5572. doi: 10.1021/ja810025g

(A) Central subunit preferences, average % inhibition of MDM2/p53 binding for the 20 mixtures containing the defined central subunit (12.5 μM/compound; 250 μM mixture). (B) C-terminus preferences for [Trp], % inhibition of MDM2/p53 binding for the 20 compound mixtures H₂N-mix-[Trp]-XXX-OH (12.5 μM/compound; 250 μM mixture). (C) N-terminus preference for [Trp]-Leu-OH, IC₅₀ values for the inhibition of MDM2/p53 binding by individual compounds H₂N-XXX-[Trp]-Leu-OH with IC₅₀ < 40 μM. Assay conditions employed were those published by Searcey et al.²⁵

(A) Central subunit preferences, average % inhibition of MDM2/p53 binding for the 20 mixtures containing the defined central subunit (12.5 μM/compound; 250 μM mixture). (B) C-terminus preferences for [Trp], % inhibition of MDM2/p53 binding for the 20 compound mixtures H₂N-mix-[Trp]-XXX-OH (12.5 μM/compound; 250 μM mixture). (C) N-terminus preference for [Trp]-Leu-OH, IC₅₀ values for the inhibition of MDM2/p53 binding by individual compounds H₂N-XXX-[Trp]-Leu-OH with IC₅₀ < 40 μM. Assay conditions employed were those published by Searcey et al.²⁵