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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: J Comb Chem. 2009 Mar–Apr;11(2):294–302. doi: 10.1021/cc8001734

Figure 2.

Figure 2

(a) Scheme showing the reactions involved in partial Edman degradation. Reagents and conditions: (a) 1:3-5 PITC:Fmoc-Cl; (b) TFA; (c) Repeat a and b four times; (d) 20% piperidine in DMF; and (e) CNBr in 70% TFA. M*, homoserine lactone. (b) Representative MS spectrum of a peptoid and its PED products derived from a 90-μm TentaGel bead carrying the sequence Npip-Nlys-Npip-Nleu-Nbsa-(Nmeg)4-Arg-Met-resin. The peaks labeled with “a” (at m/z 900.37) and “b” (at m/z 1347.50) are impurity peaks derived from library synthesis.