Figure 2.
The effect of capsaicin, capsazepine, capsaicin + SR141716A, capsaicin +SR144528 and capsaicin + capsazepine on the neurological score. Sixty mice were given 200 mg·kg−1 thioacetamide (TAA), whereas control mice received saline (n= 10). Neurological score was assessed on day 3 after treatment. Capsaicin caused significant improvement in neurological score (P < 0.01) whereas capsaicin + capsazepine (P < 0.05) impaired the beneficial effect of capsaicin. Capsazepine given alone (P < 0.05) did not produce any effect. The maximum neurological deficit score in an animal is 10. Statistical analysis was performed as described in the Methods section. Data are presented as mean ± standard error of the mean (n= 10 per group). Bars with same letter (a–c) represent group means that are significantly different. *P < 0.05, **P < 0.01, ***P < 0.001.