Table 2.
Emax (%) and pEC50 for relaxations by DEANO and 8-Br-cGMP of contractions induced by 50 mM K+ and 3 µM phenylephrine (PE)
DEANO | 8-Br-cGMP | ||
---|---|---|---|
Emax (%) | K+ | 54 ± 3 | 47 ± 13 |
PE | 105 ± 2*** | 102 ± 6*** | |
pEC50 (–logM) | K+ | 6.04 ± 0.08 | 4.36 ± 0.29 |
PE | 6.68 ± 0.16*** | 4.65 ± 0.08 |
Results show mean ± SEM, n= 5 endothelium-intact segments.
P < 0.001 phenylephrine versus K+.
DEANO, diethylamine NONOate.