Table 4. microRNAs and their target biological processes.
Process/Targets | microRNA/paralogs | |
Up regulated in this stroke study | Down regulated in this stroke study | |
Angiogenesis18 | miR-19b, -130a, -15a,-16, -222, -320 | |
Hematopoietic regulation5 | miR-16, -24, -30c, -106b, -223, | |
Immune response7 | miR-15a, -16, -24, -29a, -93, -181a, -223 | |
Lymphocyte regulation (differentiation & proliferation)7 | miR-101, -181a, -16, -24, -22, -103, -30c, let-7c | |
Cardiac/vascular function20 | miR-23a, -23b, -24, -29a, -29c, -30a,-30c, -30d -103, -222 | miR-126 |
Endothelial cell migration, differentiation and survival18 | miR-126, -222 | |
Metabolic process regulation6 | miR-130a, -29a, -29c, -320 | |
Hypoxia regulation19 | miR-23a, -23b, -24, -103, -93, -181a, -15a, -16, -101, -126, -320, let-7c, let-7e, | miR-7, let-7a |
Traumatic brain Injury (mouse brain)12 | miR-103, -130a, -185, -191, -19b, -22, -222, -223, -23a, -23b, -30c, -320, -652, -744 | |
Stroke model (blood of rat-MCAo model)11 | let-7c, miR-103, -106b, -16, -185, -191, -19b, -23a, 320, | let-7a |
Stroke model (brain of rat MCAo model)11,13 | let-7c, let-7d*, let-7e, miR-103, -126, -130a, -16, -181a, -185, -191, -222, -223, -23a, -23b, -24, -30c, -324-5p, -320,-29a, -29c, -7 | let-7a |
The biological processes that are affected by the microRNAs that are differentially expressed in the stroke samples have been analysed. List presented is based on published data.