Table 5. Unconditional logistic regression adjusted for age and multivariable analyses and estimated partial AR at death for dementia.

Neuropathological Findings	Age Adjusted Analysis			Multivariable Analysis		AR
	OR	95% CI	p-Value	OR	95% CI	Percent	95% CI
Age at death (y)
<80	1.0	—	—	1.0	—	—	—
80–89	3.2	1.8–5.5	—	2.5	1.1–5.8	8	0–16
≥90	5.2	2.9–9.4	<0.001	3.4	1.4–8.3	10	3–16
Time since last interview (y)	—	—	—	Not included	—	Not included	—
<1	1.0	—	—	—	—	—	—
>1	1.2	0.8–1.7	0.5	—	—	—	—
Brain weight for sex (g)
Low	5.7	3.2–10	<0.001	4.1	1.9–9.2	12	5–19
Average	2.0	1.2–34	—	2.1	1.0–4.2	5	0–11
High	1.0	—	—	1.0	—	—	—
Neuritic plaques in neocortex
None	1.0	—	—	1.0	—	—	—
Mild	1.2	0.7–2.2	—	1.0	—	—	—
Moderate	2.9	1.7–5.0	—	1.0	—	—	—
Severe	18.5	7.3–47	<0.001	9.7	2.1–43	8	3–14
Diffuse plaques in neocortex	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—		—
Mild	1.4	0.7–2.5	—	—	—	—	—
Moderate	1.6	0.9–2.9	—	—	—	—	—
Severe	4.2	2.3–7.9	<0.001	—	—	—	—
NFT in neocortex
None	1.0	—	—	1.0	—	—	—
Mild	1.3	0.8–2.1	—	1.0	0.5–1.8	—	—
Moderate	8.9	4.0–20	—	7.1	2.3–22	11	5–19
Severe	∞	—	<0.001	—	—	—	—
Neuritic plaques in hippocampus	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.9	1.1–3.3	—	—	—	—	—
Moderate	3.5	2.1–5.9	—	—	—	—	—
Severe	8.5	3.2–22	<0.001	—	—	—	—
Diffuse plaques in hippocampus	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.5	0.9–2.5	—	—	—	—	—
Moderate	2.0	1.1–3.5	—	—	—	—	—
Severe	2.2	0.7–7.2	0.06	—	—	—	—
Tangles in hippocampus	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.3	0.6–2.8	—	—	—	—	—
Moderate	2.7	1.2–5.9	—	—	—	—	—
Severe	8.4	3.7–19	<0.001	—	—	—	—
Neuritic plaques in the entorhinal cortex	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.9	1.1–3.1	—	—	—	—	—
Moderate	3.7	2.1–6.5	—	—	—	—	—
Severe	11.1	4.0–30	<0.001	—	—	—	—
Diffuse plaques in the entorhinal cortex	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	2.2	1.3–3.8	—	—	—	—	—
Moderate	2.6	1.5–4.4	—	—	—	—	—
Severe	5.5	2.5–12	<0.001	—	—	—	—
Tangles in entorhinal cortex	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.7	0.6–4.5	—	—	—	—	—
Moderate	3.4	1.4–8.6	—	—	—	—	—
Severe	12.7	4.8–34	<0.001	—	—	—	—
CAA
None	1.0	—	—	1.0	1.0	—	—
Mild	1.9	1.1–3.3	—	1.8	0.8–3.8	2	0–6
Moderate	4.0	2.2–7.4	—	2.9	1.2–6.8	5	1–10
Severe	∞	—	<0.001	2.9	1.2–6.8	5	1–10
Moderate/severe CAA	—	—	—	Not included	—	Not included	—
No	1.0	—	—	—	—	—	—
Yes	4.3	2.4–7.6	<0.001	—	—	—	—
Lewy bodies
No	1.0	1.0	—	1.0	—	—	—
Yes	3.2	1.5–6.9	<0.003	3.5	1.3–9.3	3	1–7
Vascular disease (VD)	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
One of infarct/lacune/haemorrhage	0.7	0.3–1.9	—	—	—	—	—
SVD only	1.6	0.9–2.8	—	—	—	—	—
Multiple	2.5	1.4–4.3	<0.004	—	—	—	—
Overall vascular pathology
None	1.0	—	—	1.0	—	—	—
Infarcts/haemorrhage	1.0	0.3–3.8	—	2.4	0.4–12	—	—
SVD/WML/lacunes	2.5	1.4–4.4	—	3.7	1.5–9.6	12	3–19
Both	2.9	1.6–5.5	<0.003	4.8	1.9–12	9	3–15
Periventricular WML	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	2.0	0.9–4.5	—	—	—	—	—
Moderate/severe	4.3	1.9–9.8	<0.001	—	—	—	—
Deep subcortical WML	—	—	—	Not included	—	Not included	—
None	1.0	—	—	—	—	—	—
Mild	1.6	1.0–2.6	—	—	—	—	—
Moderate	1.6	0.9–3.1	—	—	—	—	—
Severe	3.3	1.6–6.8	<0.01	—	—	—	—
Hippocampal atrophy
None	1.0	1.0	—	1.0	1.0	—	—
Mild	2.2	1.3–3.9	—	1.8	0.9–3.7	2	0–6
Moderate	6.9	3.7–13	—	3.4	1.5–7.5	8	2–15
Severe	11.1	2.5–50	<0.001	3.4	1.5–7.5	8	2–15
Neocortical atrophy	—	—	—	Not included	—	Not included	—
None	1.0	1.0	—	—	—	—	—
Mild	1.6	1.0–2.8	—	—	—	—	—
Moderate	5.9	3.3–10	—	—	—	—	—
Severe	37.8	5.0–29	<0.01	—	—	—	—