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. 2009 Nov 3;3(11):e540. doi: 10.1371/journal.pntd.0000540

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The robustness of the L. major promastigote drug susceptibility assay was demonstrated by screening the 1,280 compound LOPAC library in duplicate at 10 µM. The reproducibility between the two assays was R² = 0.94. Average Z-factors equaled 0.71±0.03 with a signal to background (S∶B) ratio of 20.98±0.32. (blue circle - test compound; green circle - MAX control; red circle - MIN control; and pink circle - EC₅₀ control).