Table 2.
Odds Ratios and 95% CI for Associations of Dietary Fat with Barrett’s esophagus: cases vs. population controls
| Median intake1 | # Case/control | OR (95% CI) 2 Any Barrett’s | OR (95% CI) 2 Long-segment only | |
|---|---|---|---|---|
| Total Fat (g/day) | ||||
|
| ||||
| Quartile 1 | 39.6 | 81/77 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 60.3 | 72/77 | 1.00 (0.53–1.88) | 1.86 (0.84–4.15) |
| Quartile 3 | 85.2 | 69/77 | 1.07 (0.45–2.52) | 1.07 (0.33–3.46) |
| Quartile 4 | 131.4 | 74/78 | 0.49 (0.20–1.20) | 0.52 (0.18–1.53) |
| OR per unit increase (gram) | 1.00 (0.99–1.01) | 1.01 (0.99–1.02) | ||
|
| ||||
| Saturated Fat (g/day) | ||||
|
| ||||
| Quartile 1 | 10.6 | 77/77 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 17.8 | 65/77 | 1.16 (0.64–2.12) | 1.66 (0.77–3.60) |
| Quartile 3 | 23.4 | 73/75 | 1.55 (0.71–3.36) | 3.33 (1.07–10.3) |
| Quartile 4 | 36.1 | 81/80 | 1.05 (0.47–2.34) | 1.11 (0.42–2.93) |
| OR per unit increase (gram) | 1.02 (0.99–1.05) | 1.05 (1.01–1.09) | ||
|
| ||||
| Monounsaturated fat (g/day) | ||||
|
| ||||
| Quartile 1 | 14.3 | 84/77 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 23.0 | 68/76 | 0.83 (0.45–1.54) | 1.32 (0.60–2.86) |
| Quartile 3 | 31.9 | 72/78 | 0.89 (0.40–1.94) | 1.08 (0.38–3.08) |
| Quartile 4 | 50.5 | 72/78 | 0.54 (0.23–1.28) | 0.50 (0.18–1.44) |
| OR per unit increase (gram) | 0.99 (0.97–1.02) | 1.01 (0.98–1.05) | ||
|
| ||||
| Polyunsaturated Fat (g/day) | ||||
|
| ||||
| Quartile 1 | 9.3 | 85/76 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 14.9 | 84/77 | 1.12 (0.64–1.96) | 1.35 (0.68–2.64) |
| Quartile 3 | 22.5 | 66/78 | 0.56 (0.26–1.22) | 0.38 (0.14–1.02) |
| Quartile 4 | 34.7 | 61/78 | 0.49 (0.22–1.11) | 0.47 (0.17–1.27) |
| OR per unit increase (gram) | 0.97 (0.94–0.99) | 0.98 (0.94–1.01) | ||
|
| ||||
| Trans Fat (g/day) | ||||
|
| ||||
| Quartile 1 | 2.2 | 63/77 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 3.8 | 79/76 | 1.83 (1.05–3.18) | 2.28 (1.13–4.61) |
| Quartile 3 | 5.6 | 59/78 | 1.38 (0.73–2.63) | 1.27 (0.56–3.00) |
| Quartile 4 | 8.9 | 95/78 | 1.54 (0.76–3.10) | 1.21 (0.52–2.84) |
| OR per unit increase (gram) | 1.11 (1.03–1.21) | 1.15 (1.04–1.27) | ||
|
| ||||
| Omega3 (g/day) | ||||
|
| ||||
| Quartile 1 | 0.83 | 88/76 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 1.32 | 83/78 | 0.88 (0.51–1.52) | 0.85 (0.44–1.65) |
| Quartile 3 | 2.16 | 63/77 | 0.70 (0.36–1.38) | 0.46 (0.19–1.11) |
| Quartile 4 | 3.02 | 62/78 | 0.46 (0.22–0.97) | 0.36 (0.14–0.90) |
| OR per unit increase (gram) | 0.75 (0.59–0.97) | 0.68 (0.49–0.97) | ||
|
| ||||
| Cholesterol (mg/day) | ||||
|
| ||||
| Quartile 1 | 51 | 79/77 | 1.0 (ref) | 1.0 (ref) |
| Quartile 2 | 86 | 68/77 | 1.06 (0.61–1.83) | 1.44 (0.71–2.91) |
| Quartile 3 | 237 | 81/77 | 1.89 (0.99–3.59) | 1.63 (0.69–3.85) |
| Quartile 4 | 370 | 68/78 | 0.70 (0.34–1.44) | 0.73 (0.31–1.72) |
| OR per unit increase (mg) | 1.00 (1.00–1.01) | 1.00 (0.99–1.01) | ||
1
Only dietary intake was included in the analyses. The quartile cutoff points and median intakes are from the distribution of all population controls.
2
Model was adjusted for age, sex, race (white vs. non-white), long-term vitamin use (>2 years), and energy.