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. Author manuscript; available in PMC: 2009 Oct 22.
Published in final edited form as: Pediatr Pulmonol. 2008 May;43(5):443–450. doi: 10.1002/ppul.20782

Figure. Detection of recombination hotspot in SFTPC.

Figure

With examining recombination only within the 6 kb of SFTPC using the “population cohort” (filled symbols), the background recombination rate is markedly elevated (20-25 events/kb), making it difficult to detect a hotspot (low BF, 0.24 and 5.3, European (EA) and African (AA) descent, respectively). In contrast, with examining recombination across 100 kb surrounding and including SFTPC using HapMap data (open symbols), background recombination is still elevated (6-10 events/kb), but permits detection of markedly elevated values for the Bayes factor (1446 and 1416, European [CEU] and Yoruba [YRI], respectively) . For comparison, the genome wide average recombination rate is approximately 0.4 events / kb.