Table 3.
Sensitivity analysis of the effect of dhps mutations on treatment failure by parasitemia in Rutshuru, DRC as measured by unadjusted risk differences (RD) and 95% confidence intervals (CI).
| Scenario | Parasitemia | dhps-437/540 | Risk (%) | RD | CI |
|---|---|---|---|---|---|
| All excluded failed treatment | < 45,000 | none | 24.0 | 0.* | |
| 1 mutation | 40.0 | 16 | −19, 51 | ||
| both mutations | 40.8 | 17 | −3, 37 | ||
| ≥ 45,000 | none | 23.3 | 0. | ||
| 1 mutation | 90.0 | 67 | 43, 91 | ||
| |
|
both mutations |
63.6 |
40 |
21, 59 |
| All excluded were successfully treated | < 45,000 | none | 20.0 | 0. | |
| 1 mutation | 40.0 | 20 | −14, 54 | ||
| both mutations | 35.2 | 15 | −4, 34 | ||
| ≥ 45,000 | none | 6.7 | 0. | ||
| 1 mutation | 70.0 | 63 | 34, 93 | ||
| both mutations | 51.5 | 45 | 30, 60 |
*
Referent level