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. Author manuscript; available in PMC: 2009 Oct 22.
Published in final edited form as: Pediatr Res. 2007 Aug;62(2):170–175. doi: 10.1203/PDR.0b013e3180a03232

Table 3.

Nucleotide diversity and neutrality tests in European-Americans and African-Americans for coding and non-coding regions and for synonymous and non-synonymous SNPs

Race SNP π(×10−4) θ(×10−4) Tajima's D P Fu & Li D* P
EA C 0.9 1.4 −0.66 0.51 −3.68 0.0002
NC 3.7 5.3 −0.75 0.45 −3.63 0.0003
S 0.01 0.2 −0.79 0.43 0.40 0.689
NS 1.2 1.3 −0.13 0.90 −3.50 0.0005
T 4.1 6.6 −1.0 0.32 −5.99 <0.001
AA C 1.7 2.7 −0.83 0.41 −1.87 0.062
NC 5.9 8.9 −0.95 0.34 −1.56 0.120
S 0.9 1.0 −0.19 0.85 −0.54 0.587
NS 1.2 2.5 −1.03 0.30 −1.99 0.047
T 7.2 11.0 −0.99 0.32 −2.02 0.044

C=coding; NC=non-coding; S=synonymous; NS-non-synonymous; T=total; all P values estimated assuming standard normal distribution; EA=European-American; AA=African-American; Theta (θ) is a descriptive statistic for sequence diversity based on the number of chromosomes screened and the number of polymorphisms observed. Pi (π) is a descriptive statistic for sequence diversity based upon the number of chromosomes screened and the average allele frequency of the polymorphisms identified. Tajima's D is a test statistic that compares the difference between θ and π against theoretical expectations under an evolutionary model. Fu and Li's D* compares the difference between theta and the number of singleton SNPs observed against theoretical expectations under neutrality.