Table 1.
Mutagenesis, oligomeric status and activity of plexin-B1 RBD
| Number | Mutation | Oligomeric statusa | Activityb |
|---|---|---|---|
| 1 | D1773N/D1775N | D | -c |
| 2 | W1830Y | M | Y |
| 3 | W1830S | M | Y |
| 4 | W1830F | M | Y |
| 5 | N1834D | D | N |
| 6 | Q1837M | D | Y |
| 7 | Q1837E | D | N |
| 8 | H1838S | M | Y |
| 9 | H1838W | M | - |
| 10 | H1838S/Y1839S | M | N |
| 11 | Y1839S | - | N |
| 12 | Y1839F | M | N |
| 13 | Y1839E | M | N |
Oligomeric status, D for dimer, M for monomer.
Rac1 binding activity as revealed by pull-down assay, Y: mutant binds Rac1, N: mutant does not binds Rac1
data not available