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Overexpression of ATF3 reduced mutant Htt-N63 induced toxicity. (A) Htt N63-148Q stable cells were transfected with vector or ATF3 cDNA and incubated in inducing conditions for 2 days. Cells were harvested and subjected to Western blot analysis by using anti-ATF3 and anti-actin antibodies. (B) Overexpression of ATF3 reduced mutant Htt (Htt-N63-148Q) induced toxicity using LDH-based toxicity assay. P =0.027 by Student's t-test.
