Table 1.
Transcriptional factor changes in gene expression cause by expanded polyQ Htt in PC12 cells. The mRNA levels of 20 transcription-related genes were increased up to 1.5-fold of that of control cells on day 4 after induction of mutant Htt expression. Data shows fold change of mutant Htt induction condition compare to non-induction condition.
| GenBank accession no. | Gene Product | Gene symbol | Fold change |
|---|---|---|---|
| NM_012912 | Activating transcription factor 3 | ATF3 | 24.559456 |
| NM_012953 | Fos-like antigen 1 | Fosl1 | 3.69567 |
| NM_021835 | v-jun sarcoma virus 17 oncogene homolog (avian) | v-Jun | 2.642766 |
| NM_012551 | Early growth response 1 | Egr-1 | 2.353988 |
| NM_024134 | DNA-damage inducible transcript 3 | Ddit3 | 2.06334 |
| NM_012954 | Fos-like antigen 2 | Fosl2 | 1.91767 |
| L38247 | Pancreatic and duodenal homeobox gene 1 | 1.85513 | |
| NM_053727 | Nuclear factor, interleukin 3, regulated | Nfil3 | 1.820948 |
| NM_031642 | Core promoter element binding protein | Klf6 | 1.75217 |
| NM_022715 | Major vault protein | Mvp | 1.749057 |
| BE113920 | Signal transducer and activator of transcription 3 | 1.709783 | |
| BF565718 | Core promoter element binding protein | 1.666381 | |
| NM_031599 | Eukaryotic translation initiation factor 2 alpha kinase 3 | Eif2ak3 | 1.655477 |
| AF013965 | Zinc finger protein 265 | 1.644508 | |
| BI289392 | Eukaryotic elongation factor-2 kinase | 1.590502 | |
| NM_053611 | Nuclear protein 1 | Nupr1 | 1.547344 |
| BE329377 | Jun D proto-oncogene | 1.519918 | |
| AA957545 | T-box 3 (ulnar mammary syndrome) | -1.500172 | |
| AI044110 | Thymopoietin | -1.502719 | |
| NM_031633 | Forkhead box M1 | Foxm1 | -1.851786 |