Table 3.
Sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of HMGB1, SCCA, CYFRA21-1, and CEA in parallel and serial combinations*
| Tumor marker | Sensitivity (%) | Specificity (%) | PLR | NLR |
|---|---|---|---|---|
| HMGB1 | 71.6 | 78.0 | 3.25 | 0.36 |
| SCCA | 76.3 | 70.6 | 2.60 | 0.34 |
| CYFRA21-1 | 58.3 | 66.9 | 1.76 | 0.62 |
| CEA | 48.7 | 75.6 | 1.99 | 0.68 |
| Parallel combination | 91.5 | 51.8 | 1.90 | 0.16 |
| Serial combination | 49.4 | 92.2 | 6.29 | 0.55 |
*Abbreviations: HMGB1 – high mobility group box chromosomal protein 1; SCCA – squamous cell carcinoma antigen; CYFRA21-1 – cytokeratin fragment 21-1; CEA – carcinoembryonic antigen.