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. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Neuroscience. 2009 Jul 24;163(3):877–889. doi: 10.1016/j.neuroscience.2009.07.012

Figure 1. Energy hypometabolism precedes striatal neurodegeneration.

Figure 1

(A) A Nissl-stained rat brain coronal hemisection at Bregma level +0.3 mm shows very little evidence of ipsilateral striatal structural damage 1 hr post-Rotenone (Rot) infusion. Only mild hydrocephalus was detected (arrow). (B) At 1 hr, however, cytochrome oxidase activity histochemistry revealed an area of striatal hypometabolism (asterisk) at the same Bregma level in the same subject. (C and D) No evidence of structural lesion or striatal hypometabolism was evident in vehicle-treated subjects after 7 days. Scale bar = 1 mm.