Skip to main content
. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Neuroscience. 2009 Jul 24;163(3):877–889. doi: 10.1016/j.neuroscience.2009.07.012

Figure 5. Rotenone induces complex I dysfunction in striatal mitochondria not reversible by methylene blue.

Figure 5

Compared to control, striatal mitochondria exposed to rotenone (Rot) showed a 63% decrease in complex I activity after only 3 min. MB concentrations estimated to be similar to those reached after in vivo infusion (0.5 µM) did not prevent Rot effects. High MB concentrations (5 µM and 50 µM) were also ineffective at preventing the Rot-induced complex I activity inhibition, which rules out the possibility that the neuroprotective effects of MB are due to a direct interaction with rotenone molecules or to blockade of Rot’s binding site at complex I. * = different than control, p < 0.05.