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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):2098–2108. doi: 10.1021/jm801659w

Scheme 1.

Scheme 1

Synthesis of novel 1H-imidazo-[4,5-c]quinolin-4-amine derivatives with structural variation at the 4 position.a

a Reagents: (i) m-CPBA, CHCl3/CH2Cl2/MeOH; (ii) POCl3, toluene/DMF; (iii) R-PhNH2, DMF.